Wound healing occurs naturally under physical/mechanical forces, e.g. local stretching, and in many cases, benefits from applied remedies. Here, we show how additives, e.g. honey and externally applied deformations can be used to modify and accelerate small-gap closure, simulating healing of microdamage. We measured the kinematics of cell migration during small gap closure in monolayers of NIH3T3 mouse fibroblasts and C2C12 mouse myoblasts. Addition of honey, which is typically used in wound healing (as an antibacterial), had an inverse effect on gap closure, where various evaluated concentrations slowed down gap closure rates. Concurrently, we evaluated in separate experiments the effects of externally applied stretching on the gap closure process, showing that low strains (3%) may accelerate gap closure, while medium-range strains (6%) may not be as efficient, relative to unstretched control. Thus, application of external deformations and/or various remedies can accelerate the cell migration rate in gap closure, and shorten the time required for healing of microdamage that appear at early stages of pressure injury formation.